Dynamics of Protein-Protein Interaction Network in Plasmodium Falciparum

Integration of organism-wide protein interactome data with information on expression of genes, cellular localization of proteins and their functions has proved extremely useful in developing biologically intuitive interaction networks. This chapter highlights the dynamics in protein interaction network across different stages in the lifecycle of Plasmodium falciparum, a malarial parasite, and the implication of the network dynamics in different physiological processes. The main focus of the chapter is the integration of information on experimentally derived interactions of P.falciparum proteins with expression data and analysis of the implications of interactions in different cellular processes. Extensive analysis has been made to quantify the interaction dynamics across various stages, as well as correlating it with the dynamics of the cellular pathways involving the interacting proteins. The authors’ analysis demonstrates the power of strategic integration of genome-wide datasets in extracting information on dynamics of biological pathways and processes.